Article
miR-29a/b1 Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation.
Frontiers in endocrinology - 1 Jan 2021
Guo Yang, Wu Youbing, Shi Jiahao, Zhuang Hua, Ci Lei, Huang Qin, Wan Zhipeng, Yang Hua, Zhang Mengjie, Tan Yutong, Sun Ruilin, Xu Leon, Wang Zhugang, Shen Ruling, Fei Jian
Abstract excerpt
miR-29a/b1 was reportedly involved in the regulation of the reproductive function in female mice, but the underlying molecular mechanisms are not clear. In this study, female mice lacking miR-29a/b1 showed a delay in vaginal opening, irregular estrous cycles, ovulation disorder and subfertility. The level of luteinizing hormone (LH) was significantly lower in plasma but higher in pituitary of mutant mice....
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