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Article

HNF1A variant, energy-reduced diets and insulin resistance improvement during weight loss: The POUNDS Lost trial and DIRECT.

Diabetes, obesity & metabolism - 1 Jun 2018

Huang Tao, Wang Tiange, Heianza Yoriko, Sun Dianjianyi, Ivey Kerry, Durst Ronen, Schwarzfuchs Dan, Stampfer Meir J, Bray George A, Sacks Frank M, Shai Iris, Qi Lu

Abstract excerpt

AIM: To determine whether weight-loss diets varying in macronutrients modulate the genetic effect of hepatocyte nuclear factor 1α (HNF1A) rs7957197 on weight loss and improvement of insulin resistance. MATERIALS AND METHODS: We analysed the interaction between HNF1A rs7957197 and weight-loss diets with regard to weight loss and insulin resistance improvement among 722 overweight/obese adults from a 2-year...

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PMID: 29424957
DOI: 10.1111/dom.13250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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