PCSK7 genotype modifies effect of a weight-loss diet on 2-year changes of insulin resistance: the POUNDS LOST trial.

doi:10.2337/dc14-0473

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Article

PCSK7 genotype modifies effect of a weight-loss diet on 2-year changes of insulin resistance: the POUNDS LOST trial.

Diabetes care - 1 Mar 2015

Huang Tao, Huang Jinyan, Qi Qibin, Li Yanping, Bray George A, Rood Jennifer, Sacks Frank M, Qi Lu

Abstract excerpt

OBJECTIVE: A common variant rs236918 in the PCSK7 gene has the strongest association with iron homeostasis and is related to insulin resistance. Dietary carbohydrate (CHO) modulates the genetic effect on insulin resistance. We examined whether 2-year weight-loss diets modify the effect of PCSK7 genetic variants on changes in fasting insulin levels and insulin resistance in a randomized, controlled trial. RESEARCH...

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PMID: 25504030
DOI: 10.2337/dc14-0473
PMCID: PMC4876697

Genes

PCSK7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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