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Article

Identifying multiple causative genes at a single GWAS locus.

Genome research - 1 Dec 2013

Flister Michael J, Tsaih Shirng-Wern, O'Meara Caitlin C, Endres Bradley, Hoffman Matthew J, Geurts Aron M, Dwinell Melinda R, Lazar Jozef, Jacob Howard J, Moreno Carol

Abstract excerpt

Genome-wide association studies (GWAS) are useful for nominating candidate genes, but typically are unable to establish disease causality or differentiate between the effects of variants in linkage disequilibrium (LD). Additionally, some GWAS loci might contain multiple causative variants or genes that contribute to the overall disease susceptibility at a single locus. However, the majority of current GWAS lack...

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PMID: 24006081
DOI: 10.1101/gr.160283.113
PMCID: PMC3847770

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AGTRAP
PLOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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