Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ultrasensitive detection of unknown colon cancer-initiating mutations using the example of the Adenomatous polyposis coli gene.

Cancer prevention research (Philadelphia, Pa.) - 1 Sept 2013

Gerecke Christian, Mascher Conny, Gottschalk Uwe, Kleuser Burkhard, Scholtka Bettina

Abstract excerpt

Detection of cancer precursors contributes to cancer prevention, for example, in the case of colorectal cancer. To record more patients early, ultrasensitive methods are required for the purpose of noninvasive precursor detection in body fluids. Our aim was to develop a method for enrichment and detection of known as well as unknown driver mutations in the Adenomatous polyposis coli (APC) gene. By coupled...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli Protein
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to DNA, Neoplasm

Share to Mutagenesis, Site-Directed

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 24005794
DOI: 10.1158/1940-6207.CAPR-13-0145

Genes

APC
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ultrasensitive detection of unknown colon cancer-initiating mutations using the example of the Adenomatous polyposis coli gene.PMID 24005794Read ↗

High-resolution melting assay (HRMA) is a simple and sensitive stool-based DNA Test for the detection of mutations in colorectal neoplasms.Semantic proximity Read ↗

Sensitive detection of KRAS mutations using enhanced-ice-COLD-PCR mutation enrichment and direct sequence identification.Semantic proximity Read ↗

High-resolution melting (HRM) re-analysis of a polyposis patients cohort reveals previously undetected heterozygous and mosaic APC gene mutations.Semantic proximity Read ↗

The use of COLD-PCR and high-resolution melting analysis improves the limit of detection of KRAS and BRAF mutations in colorectal cancer.Semantic proximity Read ↗

A rational two-step approach to KRAS mutation testing in colorectal cancer using high resolution melting analysis and pyrosequencing.Semantic proximity Read ↗

KRAS mutation detection and prognostic potential in sporadic colorectal cancer using high-resolution melting analysis.Semantic proximity Read ↗

KRAS mutation analysis on low percentage of colon cancer cells: the importance of quality assurance.Semantic proximity Read ↗

Screening of KRAS Mutation in Pre- and Post-Surgery Serum of Patients Suffering from Colon Cancer by COLD-PCR HRM.Semantic proximity Read ↗

Enhanced asymmetric blocked qPCR method for affordable detection of point mutations in KRAS oncogene.Semantic proximity Read ↗

Increased sensitivity of KRAS mutation detection by high-resolution melting analysis of COLD-PCR products.Semantic proximity Read ↗

KRAS mutation detection in Tunisian sporadic coloractal cancer patients with direct sequencing, high resolution melting and denaturating high performance liquid chromatography.Semantic proximity Read ↗

Detection and quantification of mutations in the plasma of patients with colorectal tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.