Article
Genetic loci that regulate healing and regeneration in LG/J and SM/J mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 2000
Blankenhorn Elizabeth P, Bryan Gregory, Kossenkov Andrew V, Clark Lise Desquenne, Zhang Xiang-Ming, Chang Celia, Horng Wenhwai, Pletscher L Susan, Cheverud James M, Showe Louise C, Heber-Katz Ellen
Abstract excerpt
MRL mice display unusual healing properties. When MRL ear pinnae are hole punched, the holes close completely without scarring, with regrowth of cartilage and reappearance of both hair follicles and sebaceous glands. Studies using (MRL/lpr x C57BL/6)F(2) and backcross mice first showed that this phenomenon was genetically determined and that multiple loci contributed to this quantitative trait. The lpr mutation...
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