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Article

A unified anti-mutant dosing strategy.

The Journal of antimicrobial chemotherapy - 1 Sept 2008

Zhao Xilin, Drlica Karl

Abstract excerpt

Antimicrobial dosing is currently attracting attention as a way to minimize the emergence of resistance. Three dose-based strategies have been advocated, each with shortcomings. Focus on killing susceptible cells overlooks resistant mutant subpopulations that may be present before treatment or generated during therapy; keeping therapeutic drug concentrations above the mutant prevention concentration (MPC;...

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Identifiers

PMID: 18544596
DOI: 10.1093/jac/dkn229
PMCID: PMC2734085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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