Article
Characterization of frequencies and distribution of single nucleotide insertions/deletions in the human genome.
Gene - 19 Jul 2006
Tan Ene-Choo, Li Haixia
Abstract excerpt
Most of the studies on single nucleotide variations are on substitutions rather than insertions/deletions. In this study, we examined the distribution and characteristics of single nucleotide insertions/deletions (SNindels), using data available from dbSNP for all the human chromosomes. There are almost 300,000 SNindels in the database, of which only 0.8% are validated. They occur at the frequency of 0.887 per 10...
Topics
- Base Pairing
- Base Sequence
- Chromosomes, Human
- DNA, Intergenic
- Exons
- Gene Frequency
- Genetic Variation
- Genome, Human
- Humans
- Introns
- Mutagenesis, Insertional
- Nucleotides
- Polymorphism, Single Nucleotide
- Reproducibility of Results
- Sequence Deletion