Using the Neandertal genome to study the evolution of small insertions and deletions in modern humans.

Abstract excerpt

BACKGROUND: Small insertions and deletions occur in humans at a lower rate compared to nucleotide changes, but evolve under more constraint than nucleotide changes. While the evolution of insertions and deletions have been investigated using ape outgroups, the now available genome of a Neandertal can shed light on the evolution of indels in more recent times. RESULTS: We used the Neandertal genome together with...

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