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Article

A homozygous truncating mutation of FGL2 is associated with immune dysregulation.

The Journal of allergy and clinical immunology - 1 Feb 2023

Janssen Erin, Alosaimi Mohammad F, Alazami Anas M, Alsuliman Abdullah, Alaiya Ayodele, Al-Saud Bandar, Al-Mousa Hamoud, Al-Zaid Tariq Jassim, Smith Emma, Platt Craig D, Alruwaili Hibah, Albanyan Sarah, Al-Mayouf Sulaiman M, Geha Raif S

Abstract excerpt

BACKGROUND: The type II transmembrane protein fibrinogen-like protein 2 (FGL2) plays critical roles in hemostasis and immune regulation. The C-terminal immunoregulatory domain of FGL2 can be secreted and is a mediator of regulatory T (Treg) cell suppression. Fgl2-/- mice develop autoantibodies and glomerulonephritis and have impaired Treg cell function. OBJECTIVE: Our aim was to identify the genetic underpinning...

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PMID: 36243222
DOI: 10.1016/j.jaci.2022.10.006

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