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Article

CYP2C83 and 4 define CYP2C8 phenotype: An approach with the substrate cinitapride.

Clinical and translational science - 1 Nov 2022

Campodónico Diana María, Zubiaur Pablo, Soria-Chacartegui Paula, Casajús Ana, Villapalos-García Gonzalo, Navares-Gómez Marcos, Gómez-Fernández Antía, Parra-Garcés Raúl, Mejía-Abril Gina, Román Manuel, Martín-Vílchez Samuel, Ochoa Dolores, Abad-Santos Francisco

Abstract excerpt

Cinitapride is a gastrointestinal prokinetic drug, prescribed for the treatment of functional dyspepsia, and as an adjuvant therapy for gastroesophageal reflux disease. In this study, we aimed to explore the impact of relevant variants in CYP3A4 and CYP2C8 and other pharmacogenes, along with demographic characteristics, on cinitapride pharmacokinetics and safety; and to evaluate the impact of CYP2C8 alleles on...

Topics

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Benzamides
Cytochrome P-450 CYP2C8
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gastroesophageal reflux and treatments

Pharmacogenetics and Drug Metabolism

Source

Open in PubMed Open full text

Identifiers

PMID: 36065758
DOI: 10.1111/cts.13386
PMCID: PMC9652446

Genes

CYP2C8
CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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