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Article

Paraoxonase-1 is a major determinant of clopidogrel efficacy.

Nature medicine - 1 Jan 2011

Bouman Heleen J, Schömig Edgar, van Werkum Jochem W, Velder Janna, Hackeng Christian M, Hirschhäuser Christoph, Waldmann Christopher, Schmalz Hans-Günther, ten Berg Jurriën M, Taubert Dirk

Abstract excerpt

Clinical efficacy of the antiplatelet drug clopidogrel is hampered by its variable biotransformation into the active metabolite. The variability in the clinical response to clopidogrel treatment has been attributed to genetic factors, but the specific genes and mechanisms underlying clopidogrel bioactivation remain unclear. Using in vitro metabolomic profiling techniques, we identified paraoxonase-1 (PON1) as the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21170047
DOI: 10.1038/nm.2281

Genes

PON1

Variants

Provenance

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Paraoxonase-1 is a major determinant of clopidogrel efficacy.PMID 21170047Read ↗

Pharmacogenomics of clopidogrel: evidence and perspectives.Semantic proximity Read ↗

Unveiling the mysteries of clopidogrel metabolism and efficacy.Semantic proximity Read ↗

Paraoxonase-1 as a Cardiovascular Biomarker in Caribbean Hispanics Patients Treated with Clopidogrel: Abundance and FunctionalitySemantic proximity Read ↗

Influence of high-density lipoprotein and paraoxonase-1 on platelet reactivity in patients with acute coronary syndromes receiving clopidogrel therapy.Semantic proximity Read ↗

Effects of cytochrome P450 2C19 and paraoxonase 1 polymorphisms on antiplatelet response to clopidogrel therapy in patients with coronary artery disease.Semantic proximity Read ↗

PON1 Q192R genotype influences clopidogrel responsiveness by relative platelet inhibition instead of on-treatment platelet reactivity.Semantic proximity Read ↗

The effects of polymorphisms in CYP2C19, ATP-binding cassette transporter B1, and paraoxonase-1 on clopidogrel treatment of Uygur patients following percutaneous coronary intervention.Semantic proximity Read ↗

The paraoxonase-1 pathway is not a major bioactivation pathway of clopidogrel in vitro.Semantic proximity Read ↗

Paraoxonase-1 as a Cardiovascular Biomarker in Caribbean Hispanic Patients Treated with Clopidogrel: Abundance and Functionality.Semantic proximity Read ↗

Paraoxonase-1 is not a major determinant of stent thrombosis in a Taiwanese population.Semantic proximity Read ↗

Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response.Semantic proximity Read ↗

Paraoxonase 1 gene polymorphism does not affect clopidogrel response variability but is associated with clinical outcome after PCI.Semantic proximity Read ↗

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