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Article

Generation of a mouse model with down-regulated U50 snoRNA (SNORD50) expression and its organ-specific phenotypic modulation.

PloS one - 1 Jan 2013

Soeno Yuuichi, Fujita Kazuya, Kudo Tomoo, Asagiri Masataka, Kakuta Shigeru, Taya Yuji, Shimazu Yoshihito, Sato Kaori, Tanaka-Fujita Ritsuko, Kubo Sachiko, Iwakura Yoichiro, Nakamura Yoshikazu, Mori Shigeo, Aoba Takaaki

Abstract excerpt

Box C/D-type small nucleolar RNAs (snoRNAs) are functional RNAs responsible for mediating 2'-O-ribose methylation of ribosomal RNAs (rRNAs) within the nucleolus. In the past years, evidence for the involvement of human U50 snoRNA in tumorigenesis has been accumulating. We previously identified U50HG, a non-protein-coding gene that hosted a box C/D-type U50 snoRNA, in a chromosomal breakpoint in a human B-cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23991050
DOI: 10.1371/journal.pone.0072105
PMCID: PMC3753356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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