Loss of multiple micro-RNAs uncovers multi-level restructuring of gene regulation in rodents

Abstract excerpt

<h4>Background</h4> The regulatory network that coordinates gene expression ultimately determines the phenotype of an organism. Micro-RNAs (miRNAs) are post-transcriptional regulators involved in key biological processes. Lineage-specific losses of multiple miRNA families are rare, and reported cases of multiple miRNA losses coincide with significant changes in gene regulation resulting in body plan modifications...

Topics

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• Chromatin
• Mammals
• RNA, Double-Stranded
• RNA Editing
• RNA, Small Interfering
• RNA, Small Nucleolar
• RNA Splicing
• Tissue Distribution

Identifiers and source

Literature Corpus work

b5156e22-f2cc-5e16-8157-0eff903ee8a7

DOI

10.1101/2024.12.05.627021