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Detection of Cytomegalovirus Drug Resistance Mutations by Next-Generation Sequencing

29 Aug 2013

Abstract excerpt

Antiviral therapy for cytomegalovirus (CMV) plays an important role in the clinical management of solid organ and hematopoietic stem cell transplant recipients. However, CMV antiviral therapy can be complicated by drug resistance associated with mutations in the phosphotransferase UL97 and the DNA polymerase UL54. We have developed an amplicon-based high-throughput sequencing strategy for detecting CMV drug...

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PMID: 23985916
DOI: 10.1128/jcm.01605-13

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