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Article

Next-generation sequencing for cytomegalovirus antiviral resistance genotyping in a clinical virology laboratory.

Antiviral research - 1 Aug 2021

Chorlton Samuel D, Ritchie Gordon, Lawson Tanya, McLachlan Elizabeth, Romney Marc G, Matic Nancy, Lowe Christopher F

Abstract excerpt

INTRODUCTION: The identification of CMV antiviral drug resistance (AVDR) is a critical diagnostic test for immunocompromised patients with CMV infection and a failure of virologic response on optimal antiviral treatment. We developed a next-generation sequencing (NGS) assay for CMV AVDR testing and compared the AVDR mutations identified by NGS to Sanger sequencing. METHODS: Retrospective review of CMV AVDR...

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Identifiers

PMID: 34174249
DOI: 10.1016/j.antiviral.2021.105123

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