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Article

Long-range PCRs and next-generation sequencing to detect cytomegalovirus drug resistance-associated mutations.

Antimicrobial agents and chemotherapy - 6 Aug 2025

Andreani Julien, Truffot Aurélie, Tilloy Valentin, Jardin Hugo, Lespinasse Matilda, Usal Marie, Larrat Sylvie, Morand Patrice, Lupo Julien, Hantz Sébastien, Alain Sophie, Germi Raphaële

Abstract excerpt

Cytomegalovirus (CMV) infections occur in 10%-40% of organ or stem cell transplant patients. Despite the low prevalence, CMV antiviral resistance has an important impact on patient outcomes. Guidelines for transplant recipients recommend that resistance should be suspected in cases of unchanged or increasing CMV viral loads after a minimum of 2 weeks of antiviral therapy at an appropriate dose or >6 weeks of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40560095
DOI: 10.1128/aac.00141-25
PMCID: PMC12326992

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