Article
Effect of mutations in domain 2 on the structural organization of oocyte 5 S rRNA from Xenopus laevis.
Journal of molecular biology - 5 Sept 1990
Brunel C, Romby P, Westhof E, Romaniuk P J, Ehresmann B, Ehresmann C
Abstract excerpt
In order to test and refine the molecular model of Xenopus laevis 5 S rRNA proposed in a previous work, we have synthesized, by site-directed mutagenesis and in vitro transcription, four mutants in the internal loop B and in the hairpin loop C of domain 2. The conformations of these mutant 5 S rRNAs have been tested using a variety of enzymatic and chemical structure-specific probes and computer modeling. The...
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