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Article

Predicting phenotypic diversity and the underlying quantitative molecular transitions.

PLoS computational biology - 1 Apr 2009

Giurumescu Claudiu A, Sternberg Paul W, Asthagiri Anand R

Abstract excerpt

During development, signaling networks control the formation of multicellular patterns. To what extent quantitative fluctuations in these complex networks may affect multicellular phenotype remains unclear. Here, we describe a computational approach to predict and analyze the phenotypic diversity that is accessible to a developmental signaling network. Applying this framework to vulval development in C. elegans,...

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PMID: 19360093
DOI: 10.1371/journal.pcbi.1000354
PMCID: PMC2661366

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