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Article

Cell atlases and the developmental foundations of the phenotype.

PLoS computational biology - 1 Feb 2026

Lou Alicia, Chagoyen Mónica, Poyatos Juan F

Abstract excerpt

It is widely acknowledged that development shapes phenotypes, yet the extent to which genes with similar expression patterns during development lead to equivalent organismal phenotypes when mutated remains unclear. Here, we propose addressing this issue, which we term the [Formula: see text]evelopment-to-[Formula: see text]henotype, or [Formula: see text]-[Formula: see text], rule, by leveraging single-cell gene...

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Identifiers

PMID: 41662466
DOI: 10.1371/journal.pcbi.1013944
PMCID: PMC12904592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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