A regulatory variant in CCR6 is associated with susceptibility to antitopoisomerase-positive systemic sclerosis.

doi:10.1002/art.38136

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Article

A regulatory variant in CCR6 is associated with susceptibility to antitopoisomerase-positive systemic sclerosis.

Arthritis and rheumatism - 1 Dec 2013

Koumakis Eugénie, Bouaziz Matthieu, Dieudé Philippe, Ruiz Barbara, Riemekasten Gabriella, Airo Paolo, Müller-Nurasyid Martina, Cusi Daniele, Matucci-Cerinic Marco, Melchers Inga, Salvi Erika, Strauch Konstantin, Peters Annette, Cuomo Giovanna, Hachulla Eric, Diot Elisabeth, Hunzelmann Nicolas, Caramaschi Paola, Riccieri Valeria, Distler Jörg H W, Tarner Ingo, Avouac Jérôme, Letenneur Luc, Amouyel Philippe, Lambert Jean-Charles, Chiocchia Gilles, Boileau Catherine, Allanore Yannick

Abstract excerpt

OBJECTIVE: Recognition of the well-known pleiotropism of autoimmune genes supports the concept of a shared pathogenesis across autoimmune diseases such as rheumatoid arthritis (RA) and systemic sclerosis (SSc). Studies have reproducibly demonstrated an association between susceptibility to RA and polymorphisms of the CCR6 gene, a surface marker for Th17 cells, and the causal variant was recently identified. The...

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PMID: 23983073
DOI: 10.1002/art.38136

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CCR6

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