The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1

Abstract excerpt

Understanding the implications of genome-wide association studies (GWAS) for disease biology requires both identification of causal variants and definition of how these variants alter gene function. The non-coding triallelic dinucleotide polymorphism CCR6DNP is associated with risk for rheumatoid arthritis, and is considered likely causal because allelic variation correlates with expression of the chemokine...

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