Article
Association of the X-chromosomal genes TIMP1 and IL9R with rheumatoid arthritis.
The Journal of rheumatology - 1 Oct 2009
Burkhardt Jana, Petit-Teixeira Elisabeth, Teixeira Vitor Hugo, Kirsten Holger, Garnier Sophie, Ruehle Sandra, Oeser Christian, Wolfram Grit, Scholz Markus, Migliorini Paola, Balsa Alejandro, Westhovens Renè, Barrera Pilar, Alves Helena, Pascual-Salcedo Dora, Bombardieri Stefano, Dequeker Jan, Radstake Timothy R, Van Riel Piet, van de Putte Leo, Bardin Thomas, Prum Bernard, Buchegger-Podbielski Ulrike, Emmrich Frank, Melchers Inga, Cornelis François, Ahnert Peter
Abstract excerpt
OBJECTIVE: Rheumatoid arthritis (RA) is an inflammatory joint disease with features of an autoimmune disease with female predominance. Candidate genes located on the X-chromosome were selected for a family trio-based association study. METHODS: A total of 1452 individuals belonging to 3 different sample sets were genotyped for 16 single-nucleotide polymorphisms (SNP) in 7 genes. The first 2 sets consisted of 100...
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