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Article

Small Hsps as Therapeutic Targets of Cystic Fibrosis Transmembrane Conductance Regulator Protein.

International journal of molecular sciences - 20 Apr 2021

Simon Stéphanie, Aissat Abdel, Degrugillier Fanny, Simonneau Benjamin, Fanen Pascale, Arrigo André-Patrick

Abstract excerpt

Human small heat shock proteins are molecular chaperones that regulate fundamental cellular processes in normal and pathological cells. Here, we have reviewed the role played by HspB1, HspB4 and HspB5 in the context of Cystic Fibrosis (CF), a severe monogenic autosomal recessive disease linked to mutations in Cystic Fibrosis Transmembrane conductance Regulator protein (CFTR) some of which trigger its misfolding...

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Identifiers

PMID: 33923911
DOI: 10.3390/ijms22084252
PMCID: PMC8072646

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