Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.

The Journal of experimental medicine - 23 Sept 2013

Maruyama Kenta, Uematsu Satoshi, Kondo Takeshi, Takeuchi Osamu, Martino Mikaël M, Kawasaki Takumi, Akira Shizuo

Abstract excerpt

Osteoclasts are multinucleated cells formed by fusion of mononuclear precursors in response to receptor activator of nuclear factor κB (NF-κB) ligand (RANKL). We found that RANKL induced expression of the DExD/H helicase family corepressor strawberry notch homologue 2 (Sbno2). Previous in vitro studies showed that Sbno2 is induced by IL-10 and is involved in NF-κB repression. However, the role of Sbno2 in vivo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Giant Cells

Share to NF-kappa B

Share to Osteoblasts

Share to Osteoclasts

Share to Osteogenesis

Share to Toll-Like Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 23980096
DOI: 10.1084/jem.20130512
PMCID: PMC3782043

Genes

MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.PMID 23980096Read ↗

Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion <i>DC‐STAMP</i>Semantic proximity Read ↗

Osteoclast Multinucleation: Review of Current LiteratureSemantic proximity Read ↗

RANKL induces heterogeneous DC-STAMP(lo) and DC-STAMP(hi) osteoclast precursors of which the DC-STAMP(lo) precursors are the master fusogens.Semantic proximity Read ↗

SBNO2 is a critical mediator of STAT3-driven hematological malignanciesSemantic proximity Read ↗

Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Regulates Osteoclast Differentiation via the Ca2+ /NFATc1 Axis.Semantic proximity Read ↗

DC-STAMP: A Key Regulator in Osteoclast DifferentiationSemantic proximity Read ↗

Mutant p62P392L stimulation of osteoclast differentiation in Paget's disease of bone.Semantic proximity Read ↗

Cutting Edge: Monarch-1 Suppresses Non-Canonical NF-κB Activation and p52-Dependent Chemokine Expression in MonocytesSemantic proximity Read ↗

Inhibiting STAT5 by the BET bromodomain inhibitor JQ1 disrupts human dendritic cell maturation.Semantic proximity Read ↗

The Association of Notch2 and NF-κB Accelerates RANKL-Induced OsteoclastogenesisSemantic proximity Read ↗

Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology.Semantic proximity Read ↗

Essential Role of DAP12 Signaling in Macrophage Programming into a Fusion-Competent StateSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.