Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology.

PloS one - 1 Jan 2015

Witwicka Hanna, Hwang Sung-Yong, Reyes-Gutierrez Pablo, Jia Hong, Odgren Paul E, Donahue Leah Rae, Birnbaum Mark J, Odgren Paul R

Abstract excerpt

The fusion of monocyte/macrophage lineage cells into fully active, multinucleated, bone resorbing osteoclasts is a complex cell biological phenomenon that utilizes specialized proteins. OC-STAMP, a multi-pass transmembrane protein, has been shown to be required for pre-osteoclast fusion and for o...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acid Phosphatase
Share to Bone Resorption
Share to Cell Fusion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lentivirus

Share to Osteoclasts

Share to Osteogenesis

Share to Tartrate-Resistant Acid Phosphatase

Source

Open in PubMed Open full text

Identifiers

PMID: 26042409
DOI: 10.1371/journal.pone.0128275
PMCID: PMC4456411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26042409-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology.PMID 26042409Read ↗

Ostm1 Bifunctional Roles in Osteoclast Maturation: Insights From a Mouse Model Mimicking a Human OSTM1 MutationSemantic proximity Read ↗

Osteoclast Multinucleation: Review of Current LiteratureSemantic proximity Read ↗

Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Regulates Osteoclast Differentiation via the Ca2+ /NFATc1 Axis.Semantic proximity Read ↗

Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion <i>DC‐STAMP</i>Semantic proximity Read ↗

SNX10 regulates osteoclastogenic cell fusion and osteoclast size in miceSemantic proximity Read ↗

RANKL induces heterogeneous DC-STAMP(lo) and DC-STAMP(hi) osteoclast precursors of which the DC-STAMP(lo) precursors are the master fusogens.Semantic proximity Read ↗

Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts.Semantic proximity Read ↗

The molecular understanding of osteoclast differentiationSemantic proximity Read ↗

Osteoclast Fusion: Time-Lapse Reveals Involvement of CD47 and Syncytin-1 at Different Stages of Nuclearity.Semantic proximity Read ↗

Developmental origin, functional maintenance and genetic rescue of osteoclastsSemantic proximity Read ↗

TAM receptors control actomyosin dynamics in osteoclasts via RHOA-COFILIN-MYOSIN II signalingSemantic proximity Read ↗

R51Q SNX10 induces osteopetrosis by promoting uncontrolled fusion of monocytes to form giant, non-functional osteoclastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.