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Article

The Association of Notch2 and NF-κB Accelerates RANKL-Induced Osteoclastogenesis

19 Aug 2008

Abstract excerpt

Notch signaling plays a key role in various cell differentiation processes including bone homeostasis. However, the specific involvement of Notch in regulating osteoclastogenesis is still controversial. In the present study, we show that RANKL induces expression of Jagged1 and Notch2 in bone marrow macrophages during osteoclast differentiation. Suppression of Notch signaling by a selective gamma-secretase...

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Identifiers

PMID: 18710934
DOI: 10.1128/mcb.00299-08

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