Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion <i>DC‐STAMP</i>

Abstract excerpt

ABSTRACT The balance between bone‐forming osteoblasts and bone‐resorbing osteoclasts is crucial to bone homeostasis, an equilibrium that is disturbed in many bone diseases. The transcription factor Tal1 is involved in the establishment of hematopoietic stem cells in the embryo and is a master regulator of hematopoietic gene expression in the adult. Here, we show that Tal1 is expressed in osteoclasts and that loss...

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