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Article

Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Regulates Osteoclast Differentiation via the Ca2+ /NFATc1 Axis.

Journal of cellular physiology - 1 Sept 2017

Chiu Ya-Hui, Schwarz Edward, Li Dongge, Xu Yuexin, Sheu Tzong-Ren, Li Jinbo, de Mesy Bentley Karen L, Feng Changyong, Wang Baoli, Wang Jhih-Cheng, Albertorio-Saez Liz, Wood Ronald, Kim Minsoo, Wang Wensheng, Ritchlin Christopher T

Abstract excerpt

DC-STAMP is a multi-pass transmembrane protein essential for cell-cell fusion between osteoclast precursors during osteoclast (OC) development. DC-STAMP-/- mice have mild osteopetrosis and form mononuclear cells with limited resorption capacity. The identification of an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) on the cytoplasmic tail of DC-STAMP suggested a potential signaling function. The absence...

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Identifiers

PMID: 27723141
DOI: 10.1002/jcp.25638
PMCID: PMC5386838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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