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Article

IFN-α regulates Blimp-1 expression via miR-23a and miR-125b in both monocytes-derived DC and pDC.

PloS one - 1 Jan 2013

Parlato Stefania, Bruni Roberto, Fragapane Paola, Salerno Debora, Marcantonio Cinzia, Borghi Paola, Tataseo Paola, Ciccaglione Anna Rita, Presutti Carlo, Romagnoli Giulia, Bozzoni Irene, Belardelli Filippo, Gabriele Lucia

Abstract excerpt

Type I interferon (IFN-I) have emerged as crucial mediators of cellular signals controlling DC differentiation and function. Human DC differentiated from monocytes in the presence of IFN-α (IFN-α DC) show a partially mature phenotype and a special capability of stimulating CD4+ T cell and cross-priming CD8+ T cells. Likewise, plasmacytoid DC (pDC) are blood DC highly specialized in the production of IFN-α in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23977359
DOI: 10.1371/journal.pone.0072833
PMCID: PMC3745402

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