CYP27B1 Gene Polymorphism rs10877012 in Patients Diagnosed with Colorectal Cancer.

doi:10.3390/nu12040998

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CYP27B1 Gene Polymorphism rs10877012 in Patients Diagnosed with Colorectal Cancer.

Nutrients - 3 Apr 2020

Latacz Maria, Snarska Jadwiga, Kostyra Elżbieta, Wroński Konrad, Fiedorowicz Ewa, Savelkoul Huub, Jarmołowska Beata, Płomiński Janusz, Grzybowski Roman, Cieślińska Anna

Abstract excerpt

Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide. Intestinal cells are CYP27B1 gene expression sites and, as a consequence, they are capable of converting pro-vitamin D into the active paracrine and autocrine forms. It was demonstrated that rs10877012 polymorphism in the CYP27B1 gene influenced the circulating vitamin D level. This provided a rationale for determining the role that...

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PMID: 32260235
DOI: 10.3390/nu12040998
PMCID: PMC7230796

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