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Article

Matrix metalloproteinase-9 inhibition improves proliferation and engraftment of myogenic cells in dystrophic muscle of mdx mice.

PloS one - 1 Jan 2013

Hindi Sajedah M, Shin Jonghyun, Ogura Yuji, Li Hong, Kumar Ashok

Abstract excerpt

Duchenne muscular dystrophy (DMD) caused by loss of cytoskeletal protein dystrophin is a devastating disorder of skeletal muscle. Primary deficiency of dystrophin leads to several secondary pathological changes including fiber degeneration and regeneration, extracellular matrix breakdown, inflamm...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred mdx

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Source

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Identifiers

PMID: 23977226
DOI: 10.1371/journal.pone.0072121
PMCID: PMC3744489

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23977226-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Matrix metalloproteinase-9 inhibition improves proliferation and engraftment of myogenic cells in dystrophic muscle of mdx mice.PMID 23977226Read ↗

Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophySemantic proximity Read ↗

MMP-10 Is Required for Efficient Muscle Regeneration in Mouse Models of Injury and Muscular DystrophySemantic proximity Read ↗

Deficiency of MMP-10 Aggravates the Diseased Phenotype of Aged Dystrophic MiceSemantic proximity Read ↗

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MyD88 is required for satellite cell-mediated myofiber regeneration in dystrophin-deficient mdx mice.Semantic proximity Read ↗

Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation.Semantic proximity Read ↗

Macrophage-released ADAMTS1 promotes muscle stem cell activation.Semantic proximity Read ↗

Toll-like receptor 4 ablation in mdx mice reveals innate immunity as a therapeutic target in Duchenne muscular dystrophySemantic proximity Read ↗

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The role of Notch signaling in muscle progenitor cell depletion and the rapid onset of histopathology in muscular dystrophySemantic proximity Read ↗

Spp1 (osteopontin) promotes TGFβ processing in fibroblasts of dystrophin-deficient muscles through matrix metalloproteinasesSemantic proximity Read ↗

Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased 7 integrin, utrophin and associated glycoproteinsSemantic proximity Read ↗

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