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Article

Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation.

Scientific reports - 31 May 2016

Arecco N, Clarke C J, Jones F K, Simpson D M, Mason D, Beynon R J, Pisconti A

Abstract excerpt

In Duchenne muscular dystrophy, progressive loss of muscle tissue is accompanied by fibrosis, chronic inflammation and reduced muscle regenerative capacity. Although much is known about the development of fibrosis and chronic inflammation in muscular dystrophy, less is known about how they are mechanistically linked to loss of muscle regenerative capacity. We have developed a proteomics method to discover...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27241590
DOI: 10.1038/srep24708
PMCID: PMC4886533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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