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Article

Macrophage-released ADAMTS1 promotes muscle stem cell activation.

Nature communications - 22 Sept 2017

Du Hongqing, Shih Chung-Hsuan, Wosczyna Michael N, Mueller Alisa A, Cho Joonseok, Aggarwal Abhishek, Rando Thomas A, Feldman Brian J

Abstract excerpt

Coordinated activation of muscle stem cells (known as satellite cells) is critical for postnatal muscle growth and regeneration. The muscle stem cell niche is central for regulating the activation state of satellite cells, but the specific extracellular signals that coordinate this regulation are poorly understood. Here we show that macrophages at sites of muscle injury induce activation of satellite cells via...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28939843
DOI: 10.1038/s41467-017-00522-7
PMCID: PMC5610267

Genes

ADAMTS1
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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