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Article

TGF-β: An emerging player in drug resistance

15 Sept 2013

Abstract excerpt

The transforming growth factor β (TGF-β) pathway acts as a double-edged sword in tumorigenesis. By constraining epithelial cell growth, TGF-β is a potent tumor suppressor. However, TGF-β also acts as a key player in the induction of epithelial-to-mesenchymal transition (EMT), thereby enhancing invasiveness and metastasis. Furthermore, TGF-β signaling has recently been correlated with resistance against both...

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PMID: 23974105
DOI: 10.4161/cc.26034

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