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Article

Transforming growth factor-β1 contributes to oxaliplatin resistance in colorectal cancer via epithelial to mesenchymal transition

19 May 2017

Abstract excerpt

Transforming growth factor‑β1 (TGF‑β1), secreted by main components of tumor microenvironment, is considered to be closely associated with cancer development and chemoresistance. The present study aimed to analyze the effects and mechanisms underlying TGF‑β1‑induced chemoresistance to oxaliplatin (LOH) in human colorectal cancer (CRC) cell lines. The cytotoxic effects of LOH subsequent to TGF‑β1 treatment were...

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PMID: 28693217
DOI: 10.3892/ol.2017.6209

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