Article
Evaluation of the potential role of a new mutation in mabA in modifying the response of Mycobacterium tuberculosis to isoniazid.
Tuberculosis (Edinburgh, Scotland) - 1 Nov 2013
Alonso María, Martínez-Lirola Miguel, Palacios Juan José, Menéndez Ángela, Herranz Marta, Martínez Susana, Bouza Emilio, García-de-Viedma Darío
Abstract excerpt
A new mutation in mabA, Thr4Ile, was identified in a Mycobacterium tuberculosis isolate from a patient whose culture remained positive after treatment. The same mutation was found in another 5 patients infected by different strains. A putative role for this mutation in the process of diminishing susceptibility to isoniazid is evaluated.
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