Article
Osteoblasts derived from induced pluripotent stem cells form calcified structures in scaffolds both in vitro and in vivo.
Stem cells (Dayton, Ohio) - 1 Feb 2011
Bilousova Ganna, Jun Du Hyun, King Karen B, De Langhe Stijn, Chick Wallace S, Torchia Enrique C, Chow Kelsey S, Klemm Dwight J, Roop Dennis R, Majka Susan M
Abstract excerpt
Reprogramming somatic cells into an ESC-like state, or induced pluripotent stem (iPS) cells, has emerged as a promising new venue for customized cell therapies. In this study, we performed directed differentiation to assess the ability of murine iPS cells to differentiate into bone, cartilage, and fat in vitro and to maintain an osteoblast phenotype on a scaffold in vitro and in vivo. Embryoid bodies derived from...
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