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Article

LINE-1 RNA triggers matrix formation in bone cells via a PKR-mediated inflammatory response

1 Jul 2024

Abstract excerpt

Transposable elements (TEs) are mobile genetic modules of viral derivation that have been co-opted to become modulators of mammalian gene expression. TEs are a major source of endogenous dsRNAs, signaling molecules able to coordinate inflammatory responses in various physiological processes. Here, we provide evidence for a positive involvement of TEs in inflammation-driven bone repair and mineralization. In newly...

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PMID: 38951609
DOI: 10.1038/s44318-024-00143-z

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