Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone.

Arthritis and rheumatism - 1 Feb 2008

Sanchez Christelle, Deberg Michelle A, Bellahcène Akeila, Castronovo Vincent, Msika Philippe, Delcour J P, Crielaard J M, Henrotin Yves E

Abstract excerpt

OBJECTIVE: To determine the phenotype of osteoblasts from the sclerotic zones of human osteoarthritic (OA) subchondral bone. METHODS: Human osteoblasts were isolated from sclerotic or nonsclerotic areas of subchondral bone and cultured for 14 days in monolayer. The expression of 14 genes was investigated by real-time reverse transcription-polymerase chain reaction. The activities of alkaline phosphatase (AP) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Collagen Type I, alpha 1 Chain
Share to Knee Joint

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Matrix Metalloproteinase 13

Share to Osteocalcin

Share to Osteopontin

Share to Phosphate Transport Proteins

Share to Sclerosis

Share to Transglutaminases

Source

Identifiers

PMID: 18240211
DOI: 10.1002/art.23159

Genes

ANKH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone.PMID 18240211Read ↗

Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes.Semantic proximity Read ↗

Phenotypic characterization of osteoarthritic osteocytes from the sclerotic zones: a possible pathological role in subchondral bone sclerosis.Semantic proximity Read ↗

Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1beta and oncostatin M pre-treated non-sclerotic osteoblasts.Semantic proximity Read ↗

Alterations of Subchondral Bone Progenitor Cells in Human Knee and Hip Osteoarthritis Lead to a Bone Sclerosis Phenotype.Semantic proximity Read ↗

Bone phenotypes in rheumatology - there is more to bone than just bone.Semantic proximity Read ↗

Can altered production of interleukin-1beta, interleukin-6, transforming growth factor-beta and prostaglandin E(2) by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients.Semantic proximity Read ↗

Osteoblast Role in Rheumatic DiseasesSemantic proximity Read ↗

Osteoblast role in the pathogenesis of rheumatoid arthritisSemantic proximity Read ↗

Subchondral bone and osteoarthritis: biological and cellular aspects.Semantic proximity Read ↗

Osteoblast role in osteoarthritis pathogenesis.Semantic proximity Read ↗

Osteoblast-like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: possible role in subchondral bone sclerosis.Semantic proximity Read ↗

Circulating mesenchymal stem cells with abnormal osteogenic differentiation in patients with osteoporosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.