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In Osteoporosis, differentiation of mesenchymal stem cells (MSCs) improves bone marrow adipogenesis

1 Jan 2012

Abstract excerpt

The formation, maintenance, and repair of bone tissue involve close interlinks between two stem cell types housed in the bone marrow: the hematologic stem cell originating osteoclasts and mesenchymal stromal cells (MSCs) generating osteoblasts. In this review, we consider malfunctioning of MSCs as essential for osteoporosis. In osteoporosis, increased bone fragility and susceptibility to fractures result from...

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PMID: 23283437
DOI: 10.4067/s0716-97602012000300009

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