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Article

Caveolin-1 deficiency stimulates neointima formation during vascular injury.

Biochemistry - 6 Jul 2004

Hassan Ghada S, Jasmin Jean-François, Schubert William, Frank Philippe G, Lisanti Michael P

Abstract excerpt

Neointima formation is a process characterized by smooth muscle cell (SMC) proliferation and extracellular matrix deposition in the vascular intimal layer. Here, we critically evaluate the role of caveolin-1 (Cav-1) in the pathogenesis of neointima formation. Cav-1 and caveolae organelles are particularly abundant in SMCs, where they are thought to function in membrane trafficking and signal transduction events....

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Identifiers

PMID: 15222744
DOI: 10.1021/bi049609t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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