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Article

Genetic Evidence for an Interferon-Antagonistic Function of Rift Valley Fever Virus Nonstructural Protein NSs

1 Feb 2001

Abstract excerpt

Rift Valley fever virus (RVFV), a phlebovirus of the family Bunyaviridae, is a major public health threat in Egypt and sub-Saharan Africa. The viral and host cellular factors that contribute to RVFV virulence and pathogenicity are still poorly understood. All pathogenic RVFV strains direct the synthesis of a nonstructural phosphoprotein (NSs) that is encoded by the smallest (S) segment of the tripartite genome...

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Identifiers

PMID: 11152510
DOI: 10.1128/jvi.75.3.1371-1377.2001

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Related research

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Genetic Evidence for an Interferon-Antagonistic Function of Rift Valley Fever Virus Nonstructural Protein NSsPMID 11152510Read ↗

NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase.Semantic proximity Read ↗

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and EfficacySemantic proximity Read ↗

The Change P82L in the Rift Valley Fever Virus NSs Protein Confers Attenuation in Mice Not Related with a Type-I IFN Antagonistic PhenotypeSemantic proximity Read ↗

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The Change P82L in the Rift Valley Fever Virus NSs Protein Confers Attenuation in MiceSemantic proximity Read ↗

The dominant-negative inhibition of double-stranded RNA-dependent protein kinase PKR increases the efficacy of Rift Valley fever virus MP-12 vaccine.Semantic proximity Read ↗

Rift Valley Fever Virus Lacking the NSs and NSm Genes Is Highly Attenuated, Confers Protective Immunity from Virulent Virus Challenge, and Allows for Differential Identification of Infected and Vaccinated AnimalsSemantic proximity Read ↗

Rift Valley Fever Virus NSs Protein Promotes Post-Transcriptional Downregulation of Protein Kinase PKR and Inhibits eIF2α PhosphorylationSemantic proximity Read ↗

Rescue of infectious rift valley fever virus entirely from cDNA, analysis of virus lacking the NSs gene, and expression of a foreign gene.Semantic proximity Read ↗

NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription.Semantic proximity Read ↗

Paramyxovirus Accessory Proteins as Interferon AntagonistsSemantic proximity Read ↗

Inhibition of interferon induction and signaling by paramyxovirusesSemantic proximity Read ↗

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