Article
GarA is an essential regulator of metabolism in Mycobacterium tuberculosis.
Molecular microbiology - 1 Oct 2013
Ventura Marcello, Rieck Barbara, Boldrin Francesca, Degiacomi Giulia, Bellinzoni Marco, Barilone Nathalie, Alzaidi Faisal, Alzari Pedro M, Manganelli Riccardo, O'Hare Helen M
Abstract excerpt
Alpha-ketoglutarate is a key metabolic intermediate at the crossroads of carbon and nitrogen metabolism, whose fate is tightly regulated. In mycobacteria the protein GarA regulates the tricarboxylic acid cycle and glutamate synthesis by direct binding and regulation of three enzymes that use α-ketoglutarate. GarA, in turn, is thought to be regulated via phosphorylation by protein kinase G and other kinases. We...
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