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Article

Metabolic regulation of mycobacterial growth and antibiotic sensitivity.

PLoS biology - 1 May 2011

Baek Seung-Hun, Li Alice H, Sassetti Christopher M

Abstract excerpt

Treatment of chronic bacterial infections, such as tuberculosis (TB), requires a remarkably long course of therapy, despite the availability of drugs that are rapidly bacteriocidal in vitro. This observation has long been attributed to the presence of bacterial populations in the host that are "drug-tolerant" because of their slow replication and low rate of metabolism. However, both the physiologic state of...

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Identifiers

PMID: 21629732
DOI: 10.1371/journal.pbio.1001065
PMCID: PMC3101192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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