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Article

Poor association between dihydropyrimidine dehydrogenase (DPYD) genotype and fluoropyrimidine-induced toxicity in an Asian population.

Cancer medicine - 1 Apr 2023

Kanai Masashi, Kawaguchi Takahisa, Kotaka Masahito, Manaka Dai, Hasegawa Junichi, Takagane Akinori, Munemoto Yoshinori, Kato Takeshi, Eto Tetsuya, Touyama Tetsuo, Matsui Takanori, Shinozaki Katsunori, Matsumoto Shigemi, Mizushima Tsunekazu, Mori Masaki, Sakamoto Junichi, Ohtsu Atsushi, Yoshino Takayuki, Saji Shigetoyo, Matsuda Fumihiko

Abstract excerpt

OBJECTIVE: Dihydropyrimidine dehydrogenase (DPYD) genotype is closely associated with fluoropyrimidine (FP)-induced toxicities in Caucasian population and European Medicines Agency now recommends DPYD genotype-based FP dosing strategy. PATIENTS AND METHODS: The current study aimed to investigate their impact on FP-related toxicities in an Asian population using genome-wide association study (GWAS) data set from...

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Identifiers

PMID: 36524458
DOI: 10.1002/cam4.5541
PMCID: PMC10134304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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