Article
Implementation of upfront DPYD genotyping with a low-cost and high-throughput assay to guide fluoropyrimidine treatment in cancer patients.
Pharmacogenetics and genomics - 1 Oct 2023
Pinheiro Manuela, Peixoto Ana, Rocha Patrícia, Santos Catarina, Escudeiro Carla, Veiga Isabel, Porto Miguel, Guerra Joana, Barbosa Ana, Pinto Carla, Arinto Patrícia, Resende Adriana, Teixeira Manuel R
Abstract excerpt
OBJECTIVES: Genetic variants in the dihydropyrimidine dehydrogenase (DPYD ) gene are associated with reduced dihydropyrimidine dehydrogenase enzyme activity and can cause severe fluoropyrimidine-related toxicity. We assessed the frequency of the four most common and well-established DPYD variants associated with fluoropyrimidine toxicity and implemented a relatively low-cost and high-throughput genotyping assay...
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