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Article

Two-state dynamics of the SH3-SH2 tandem of Abl kinase and the allosteric role of the N-cap.

Proceedings of the National Academy of Sciences of the United States of America - 3 Sept 2013

Corbi-Verge Carles, Marinelli Fabrizio, Zafra-Ruano Ana, Ruiz-Sanz Javier, Luque Irene, Faraldo-Gómez José D

Abstract excerpt

The regulation and localization of signaling enzymes is often mediated by accessory modular domains, which frequently function in tandems. The ability of these tandems to adopt multiple conformations is as important for proper regulation as the individual domain specificity. A paradigmatic exampl...

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Share to Calorimetry, Differential Scanning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-abl

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Identifiers

PMID: 23959873
DOI: 10.1073/pnas.1303966110
PMCID: PMC3767523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23959873-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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