Article
Generation of human metabolites of 7-ethoxycoumarin by bacterial cytochrome P450 BM3.
Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2008
Kim Dong-Hyun, Kim Keon-Hee, Kim Dae-Hwan, Liu Kwang-Hyeon, Jung Heung-Chae, Pan Jae-Gu, Yun Chul-Ho
Abstract excerpt
Recently, wild-type and mutant forms of bacterial cytochrome P450 BM3 (CYP102A1) have been found to metabolize various drugs through reactions similar to those catalyzed by human cytochromes P450 (P450s). Therefore, it has been suggested that CYP102A1 may be used to produce large quantities of th...
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