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Article

Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.

The Journal of biological chemistry - 4 Oct 2013

Dong Liang, Sharma Narayan P, Jurban Brice J, Smith William L

Abstract excerpt

Prostaglandin endoperoxide H synthase-2 (PGHS-2), also known as cyclooxygenase-2 (COX-2), is a sequence homodimer. However, the enzyme exhibits half-site heme and inhibitor binding and functions as a conformational heterodimer having a catalytic subunit (Ecat) with heme bound and an allosteric subunit (Eallo) lacking heme. Some recombinant heterodimers composed of a COX-deficient mutant subunit and a native...

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Identifiers

PMID: 23955344
DOI: 10.1074/jbc.M113.505503
PMCID: PMC3789963

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Source receipt: pubmed, retrieved 7 Sept 2026.

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